The detrimental effects of different knee pathologies on the joint cartilage
The adult joint cartilage has limited regeneration capacity. The balance between synthesis and degradation can be determined by the measurement of matrix proteins in the synovial fluids. In this study, the detrimental effects of different knee pathologies were investigated by measuring the proteoglycans degradation products in synovial fluids. Eighty six patients with unilateral knee pathologies were included in the study and classified as follow; meniscal lesion (Group I, n=36), chronic ACL and meniscal lesion (Goup II, n=15), isolated subacute chronic ACL lesion (group III, n=8), patellar pain (Group IV, n=14), gonarthrosis (Group V, n=13), normal control (NC, n=9). The level of proteoglycan degradation products in pathological knees was significantly higher than those in the normal knees. Group II had statistically significantly higher values than group I (p<0.05). These data show that the cartilage matrix turnover is strongly effected by the internal derangement of the knee joint. Long-term monitorization is needed to clarify whether the imbalance of cartilage matrix turnover can eventually cause the osteoarthritis.
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