Resection of the whole femur, together with endoprosthetic replacement is a major limb-salvaging procedure. We performed total femoral resection and endoprosthetic replacement with TMTS (Turkish Musculoskeletal Tumor Society) prosthesis in two young (20 years old) male patients with stage-IIB osteosarcoma. Postoperative complications were only temporary sciatic nerve neuropraxia and minor skin necrosis around the surgical wound. After a four-staged individualized rehabilitation program, both patients were able to walk without any support or limitation. At the end of a follow-up period of 22 and 26 months, both patients achieved a nearly full range of motion of the knee and the hip, with Enneking functional scores being excellent. Endoprosthetic total femoral reconstruction results in satisfactory oncologic and functional outcome in selected patients.