Acta Orthopaedica et Traumatologica Turcica
Research Article
Locally administrated single-dose teriparatide affects critical-size rabbit calvarial defects: A histological, histomorphometric and micro-CT study

Locally administrated single-dose teriparatide affects critical-size rabbit calvarial defects: A histological, histomorphometric and micro-CT study

1.

Hacettepe University, Department of Oral and Maxillofacial Surgery, Turkey

2.

Gazi University, Department of Oral Pathology, Turkey

3.

Hacettepe University, Department of Anatomy, Turkey

4.

Vocational School of Health, Ankara University, Ankara, Turkey

AOTT 2019; 53: 478-484
DOI: 10.1016/j.aott.2019.08.007
Read: 282 Downloads: 117 Published: 24 December 2019

Objective: The aim of this study was to evaluate the effect of teriparatide (PTH 1-34, rhPTH) on a rabbit defect model with local xenogen grafts histomorphometrically and radiologically.

Methods: For this purpose, two 10 mm diameter critical-size defects were created in the calvaria of 16 rabbits. In the control group, the defect area was filled with a xenogen graft, while in the teriparatide group (PTH 1-34), a xenogen graft combination with 20 mcg teriparatide was used. For both 4 e week and 8 e week study groups, new bone, residual graft, and soft tissue areas were evaluated as well as bone volume histomorphometrically and radiologically.

Results: Histomorphometrically, there was a significant difference in new bone area values at the 8th week (p < 0.05), but there was no significant difference between the 4 e week values (p > 0.05). There was no statistically significant difference between the groups at both 4 and 8 weeks (p > 0.05). In the radiologically measured total bone volume values, PTH1-34 group values were found to be significantly higher for both 4 e and 8 e weeks values compared to the control groups (p < 0.05).

Conclusion: In this study, rhPTH, which is used locally in defect areas to be repaired with bone grafts, increases both new bone volume and total bone volume.

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ISSN 1017-995X EISSN 2589-1294